临床时讯 ＞ 临床研究
美国学者报告，大多数发生急性胰腺炎的妊娠妇女无并发症，流产和早产主要发生在妊娠早期，弥散性血管内凝血（DIC）多发生在妊娠晚期。该研究发表于《临床胃肠病学与肝脏病学》（Clinical Gastroenterology and Hepatology）杂志。
Clin Gastroenterol Hepatol. 2010 Jan;8(1):85-90.
Acute pancreatitis during pregnancy.
Tang SJ, Rodriguez-Frias E, Singh S, Mayo MJ, Jazrawi SF, Sreenarasimhaiah J, Lara LF, Rockey DC.
Department of Gastroenterology, Hepatology & Endoscopy, Trinity Mother Frances Hospitals and Clinics, Tyler, Texas, USA.
BACKGROUND & AIMS: Acute pancreatitis is rare during pregnancy; limited data are available about maternal and fetal outcomes. We investigated the effects of acute pancreatitis during pregnancy on fetal outcome. METHODS: This retrospective cohort study, performed at a single academic center, included consecutive pregnant women who presented with (n = 96) or developed acute pancreatitis in the hospital (n = 7) in 2000-2006 (mean age, 26 y). Patient histories and clinical data were collected from medical records. RESULTS: Of the 96 patients with spontaneous pancreatitis, 4 had complications: 1 patient in the first trimester had acute peripancreatic fluid collection, and 3 patients in the third trimester developed disseminated vascular coagulation (DIC). None of these patients achieved term pregnancy, and 1 of the patients with DIC died. Endoscopic retrograde cholangiopancreatography (ERCP) was performed in 23 patients with acute pancreatitis; post-ERCP pancreatitis was diagnosed in 4 patients (a total of 11 patients developed ERCP-associated pancreatitis). Term pregnancy was achieved in 73 patients (80.2%). Patients who developed pancreatitis in the first trimester had the lowest percentage of term pregnancy (60%) and highest risks of fetal loss (20%) and preterm delivery (16%). Of the patients with pancreatitis in the second and third trimesters, only one had fetal loss. Fetal malformations were not observed. CONCLUSIONS: The majority of pregnant patients with acute pancreatitis did not have complications; most adverse fetal outcomes (fetal loss and preterm delivery) occurred during the first trimester. Acute pancreatitis, complicated by DIC, occurred most frequently in the third trimester and was associated with poor fetal and maternal outcomes.